Serrapetase did nothing for me. I've taken it for other issues, but I got no relief and actually got worse while taking this. DE seems to be working along with ACV/BSM. I have gone to a wide shoe/boot in every style and sticking soft pads 1/4 in thick under my high arch. Its a fine line between that second toe joint and my arch, if its on the joint, I get worse. Just back of it seems to help. I am hoping this will allow me to forego surgery and podiatrist believes it will eventually.