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Just wanted to give an update to this article with this new study (April 2024) that adds a bit more confirmatory data and mechanisms of action to the idea that melatonin is useful for osteoporosis :
https://pubmed.ncbi.nlm.nih.gov/38618998/
Here is a relevant study quote :
' Notably, MLT significantly increased the production of short-chain fatty acids and decreased trimethylamine N-oxide-related metabolites. Importantly, MLT could modulate the dynamic balance of M1/M2 macrophages, reduce the serum levels of pro-inflammatory cytokines, and restore gut-barrier function. Taken together, our results highlighted the important roles of gut microbially derived MLT in OP progression via the "gut-bone" axis associated with SCFA metabolism, which may provide novel insight into the development of MLT as a promising drug for treating OP. '
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Article Updates
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I am posting this as an update to the recent article on osteoporosis (9/7/23). I forgot to include one supplement that I had on my list for the article and am adding another supplement. By adding these two supplements, it gives the readers more choices in case any of the supplements cause unwanted side effects, you will have the option to replace it.
Berberine
The supplement I forgot is Berberine, which has, in recent studies, suggested benefit for bone regeneration in osteoporosis as discussed in the following link :
https://www.sciencedirect.com/science/article/abs/pii/S0378874121004761?via=ihub
Here is a relevant quote from the review :
- ' Berberine has a long history of medicinal use to treat various diseases including bone disease in China. Recent studies have defined its function in promoting bone regeneration and great potential in developing new drugs. '
Berberine is generally found in 500 mg capsules and is often used at 1000 to 1500 mg/day in divided doses.
Selenium
The second supplement is Selenium and selenium has shown that higher levels in the body are associated with improved bone mineral density (BMD) and lower levels of selenium are associated with increased risk for osteoporosis as discussed here in this 2023 meta analysis of multiple studies. Selenium supplements are generally available in 200 mcg capsules and Selenomethionine is considered to be a good form :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322231/
Here is a relevant quote from the meta analysis :
' From 748 non-duplicate publications, 19 studies were included. We found a significantly positive association between dietary selenium intake (β = 0.04,95% confidence interval (CI) 0.00 to 0.07, p = 0.029) as well as serum selenium (β = 0.13,95% CI 0.00 to 0.26, p = 0.046) and BMD. Consistently, those with higher selenium intake had a lower risk of OP (OR = 0.47,95% CI 0.31 to 0.72, p = 0.001), and patients with OP had a significantly lower level of serum selenium than healthy controls (WMD = -2.01,95% CI -3.91 to -0.12, p = 0.037). High dietary selenium intake was associated with a lower risk of hip fracture (OR = 0.44,95% CI 0.37 to 0.52, p < 0.001). '
So the addition of these two supplements can potentially be additive to the original supplements and can offer alternate choices for a person who does not tolerate a supplement from the original list.
Here is the new complete list of supplements :
1. Magnesium
2. Vitamin K2
3. Strontium Citrate
4. Boron
5. Vitamin B6
6. Vitamin D
7. Berberine
8. Selenium
9. Melatonin
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