Melatonin Protocol for COVID-19

Melatonin and What Type May Be Best for Covid-19:

Previously I had stated that when it comes to Covid-19, the type of melatonin should not be an issue, but Dr. Neel had stated that he was using the type of melatonin that dissolves in the mouth or under the tongue (sublingual).

I thought the only significance of that type was that he felt it would be possible to give to patients already on a ventilator and that was it, but this recent report suggests that there may be more to sublingual melatonin than that! Other sublingual supplements are often said to have better bioavailability in their sublingual forms over regular capsules or pills. Perhaps this is also true for melatonin in its sublingual form? Melatonin on its own has poor bioavailability. Roughly, oral melatonin only offers a maximum of 15% bioavailability at best. So this offers some creedence that even a small increase in bioavailability may have significant ramifications when it comes to melatonin?

https://pubmed.ncbi.nlm.nih.gov/10883420/#:~:text=Subjects were administered, in a, absolute bioavailability of approximately 15%.

Given that information, the following report from a Covid-19/Melatonin patient makes a little more sense and I may need to rethink the use of sublingual melatonin on the chance that it is better absorbed by the human body???

https://devinenews.com/family-of-8-hit-hard-by-coronavirus/

Perhaps type of melatonin does matter??? Since I have been taking melatonin in the capsule form, I may have to get a bottle of sublingual melatonin to see if I respond differently to it? This may take a little bit of time since I have other experiments already in my queue.

Art

Hi M to M!

Thank you for saying so! I know you are probably already aware of the following, but I am putting it in for others who may not be. COPD is common, so it is worth putting this info up. Some people refer to it as emphysema, but that is an older term and COPD seems more common now as a blanket term. There are some similarities with chronic bronchitis.I'm not sure about the H2O2 for COPD simply for lack of studies to add confirmation to the anecdotal evidence, but the anecdotal evidence is compelling.

In COPD patients who are stable, the amount of H2O2 in the exhaled air is approximately 7 times that of normal controls while patients who are in an exacerbated state are almost 3 times higher than stable patients and about 21 times higher than control patients.

So H2O2 inhalation will add to these already significantly elevated H2O2 levels. This brief abstract discusses H2O2 exhalation levels in people with COPD:

https://www.atsjournals.org/doi/10.1164/ajrccm.154.3.8810624

Melatonin clearly has studies that show it benefits COPD as does NAC, which is purported to significantly reduce exacerbations at two 600 mg doses per day.

Generally elevated oxidative stress is considered to possibly be the single most important factor driving COPD disease progression, so these two seem quite useful and melatonin is the most potent antioxidant in the human body as I described in the original post. Maximum radical scavenging is desirable.HDM made it possible for me to get rid of a cough that I had had for months that was not getting better, only worse. With HDM it started to lessen in two days and was gone by the third day.Vitamin C is synergistic with melatonin and adds to both its antioxidant abilities as well as its antiinflammatory qualities.Quercetin is also useful for COPD and quercetin is also synergistic with melatonin increasing its antiinflammatory activity.

Vitamin D reduces the number of acute exacerbations also and it is almost always good to be vitamin D replete for overall health, especially with so many people being insufficient or deficient. Getting into the upper half of the reference range for 25 OH d is worth looking into at whatever vitamin D dose is needed to get there. Simply put, some people require more vitamin D to achieve a specific 25 OH d level. The 25 OH d reference range is 30 ng/ml ~ 100 ng/ml

Some essential oils such as eucalyptus are thought to be helpful with COPD also. Not everyone can tolerate melatonin. Does your mother in law have Afib?

Art

You can always do the usual anti-virus things--vit C and D, lysine, chicken soup, healthy diet, plenty of water, sleep, fresh air and sunshine. Melatonin surely can't hurt and may help. Whenever I am exposed to anything, even stress, I try to fall back on the tried and true remedies.

Dr. Neel is recommending adult patients take 80 mg of melatonin every 24 hours and has seen improvement in each of his patients in just 24 hours with a reduction in symptoms. Since that is his suggestion and it is my intention to use melatonin if I were to get Covid-19, assuming I have not already had it, I tried taking 80 mgs last night in 4 divided doses. I took 20 mgs at 7:00 pm, 20 mg at 8:30 pm, 20 mg at 10 pm and 20 mg at 11:30 pm. I woke up this morning expecting the "melatonin hangover" that I initially felt in a previous months long test of melatonin at 70 mg, but to my surprise, there was no melatonin hangover! I actually felt quite rested and not sluggish at all! I did not include vitamin C even though he has mentioned its use with the melatonin because in the Doctor's Hospital trial of melatonin, they didn't use vitamin C and they got rapid results with melatonin, so I just thought I would keep it simple for now. Well that and my vitamin C order has not arrived yet! To be fair, I do take 30 mg of melatonin a night in 3 divided doses as what I have previously described as melatonin 123, almost every night, so I'm sure that is a contributing factor to why going from 30 mg to 80 mg didn't produce the hangover or have any other obvious effect on me. So now I know that 80 mg / day of melatonin should not be a problem for me and again, I reiterate that I am not recommending that anyone else do what I am doing, I am only describing my own experience. If anyone chooses to utilize Dr. Neels melatonin protocol it should be done under a doctor's supervision in order to be safe and make sure melatonin is compatible with everything you are taking. I have an idea (speculation at this time) about melatonin and Covid-19 that is based on the available literature about melatonin and Dr. Neel's results in his small group of patients as well as the little information that the Doctors Hospital in Manila has shared so far. I think that melatonin may alter the immune environment in such a way that the virus can not cause a cytokine storm or allow pneumonia to get started because melatonin's potent reactive oxygen species scavenging abilities as well as its reactive nitrogen species scavenging abilities in conjunction with its potent antiinflammatory qualities including inhibition of IL-6 and other inflammatory mediators and inhibition of lung inflammation by way of modulated expression of Apelin 13 as well as inhibition of NLRP3 inflammasome, very effectively seems to reduce lung inflammation and damage to a level that is no longer dangerous and it does it very quickly based on Dr. Neels results. In the Philippines, it even seems to work fast and well with patients who already have pneumonia. Three main things attributed to Covid-19 that has shown the ability to kill patients are severe Covid-19 induced pneumonia, the now famous cytokine storm and the addition of a ventilator. Melatonin seems to be able to prevent or ameliorate the first two items which automatically ends the need for a ventilator! Melatonin is also protective of all major organs which is important since autopsies are showing liver, lung, kidneys and heart damage that is attributed to Covid-19. Viral particles are also found in the brain, so it is felt that it is possible that Covid-19 could also cause damage to the brain if not checked early enough. So if you eliminate or greatly limit the 3 ways that Covid-19 has shown the ability to kill patients, then how much of a threat is Covid-19 once melatonin is introduced? My speculative answer to that question is very minimal. All of these actions of melatonin that work contrary to the normal disease process can allow the body to do what it is naturally supposed to do, destroy invaders to the system which in this case if the SARS CoV-2 virus. The body can now defend itself without the deadly cytokine storm, against the now marginalized virus. This is what studies suggest as possible and what Dr. Neel is showing in his patients which means that the studies tend to confirm Dr. Neels results and those results tend to confirm the studies. Given the above, melatonin seems to convert the killer virus into something that is not deadly at all. If the virus mutates as it has already with the known A strain, B strain and C strains that are already seen in different areas, there is a chance that by the time a vaccine is developed, it may not be effective against the current strain if that strain has mutated extensively. These mutations have occurred fairly quickly suggesting that extensive mutation is a very real prospect when it comes to SARS CoV-2. Whereas the known actions of melatonin are likely to be able to deal with mutations of this virus. It will take further testing of melatonin against SARS CoV-2 in Covid-19 patients to take this from speculation to fact, but if Dr. Neel's patient base continues to grow and other doctors take his lead as it appears may be likely, then that point of clarification and understanding may not be far away at all. Melatonin is showing the potential, via its ability to control and reverse the ability of Covid-19 to be so destructive within the human body, to actually take many people in the "at risk groups"off of that list! So this could make the virus more of a nuisance than a killer! Melatonin may actually be the answer to safely controlling the virus while allowing the economy to open again because it makes the virus tolerable to humans with minimal to no deleterious effects. Yes, people will still get infected, but melatonin appears to make such infection "livable" while allowing the body to make plenty of antibodies against SARS CoV-2. Still speculation at this point, but continued positive reports on melatonin can potentially turn speculation to reality! My other thought is, how many other practical choices do we have with what is currently known and available? Art

Marshagail,

Thank you very much for your kind and thoughtful words!

Art

Paola,

If the reason you are taking melatonin is to fight Covid, it only need be taken while you have Covid and up to 2 months after as a long Covid preventative.

The topic of retinal damage and melatonin was based on an old study in animals, where they gave high dose melatonin and then exposed them to very bright light which caused damage. First the melatonin was taken during the day when melatonin levels are lower. Most studies I have seen recommend and use melatonin at night and this is what I do also. Melatonin levels are normally higher at night and lower during the daylight hours. What was done to the animals in that study I would consider a form of torture.

So this was an abnormal use of melatonin and very bright light which humans don't regularly do. I only mention daytime use of melatonin for severe diseases such as Covid or cancer. In any case I have not seen similar results in human studies, but I have seen newer studies that suggest that melatonin use has beneficial effects for the retinas as discussed in this newer (May 2023) review of studies :

https://www.sciencedirect.com/science/article/pii/S0753332223002640

Here are two relevant quotes :

' MT synthesis-related genes in retinal tissue may be affected by age. Our study shows that MT can effectively restore NaIO3-induced retinopathy and maintain retinal structural integrity. Importantly, MT may assist the conversion of M1 to M2 macrophages to promote tissue repair, which may be caused by the increased infiltration of Tregs. Moreover, MT treatment may upregulate TET2, and further NT5E demethylation is associated with Treg recruitment in the retinal microenvironment. '

' Our findings suggest that MT can effectively ameliorate retinal degeneration and regulate immune homeostasis via Tregs. Modulation of the immune response may provide a key therapeutic strategy. '

The science of melatonin is continually evolving as new studies discover more positive effects that melatonin has on human, animal and plant health.

I have taken higher dose melatonin for over a decade based on studies I have read. I currently take my 132 mg of melatonin in the evening.

Art

I hate to be one of the few, to point it out to you, however, there are some of us that went and did the work and read the studies out there on mRNA treatments. Who understand what "Emergency Use" means. I took my time to do what the Doctors are paid to do yet didn't. The few Docs that did read into things were penalized if they didn't toe the line. So get it straight, there isn't no politics here. I hate Donald Trump he is part of the WARP SPEED problem and still trying to convince people to use that poison. I will say this. My who family there are about 60 of us in total none of us did any of the crazy protocols and none of us died, not even our old people. FF a year later, I know of about 3 folks who have died. One was my son's 25 year old best friend! I highly recommend the leukemia study where they used mRNA to treat terminally ill patients, the gene therapy (mRNA) turned off their tumor suppressing gene. Yes, read that again TURNED OFF THE TUMOR SUPPRESSING GENE. That means you grow CANCER! Do you have the money and the time to spend at the hospital for taking an experimental concoction? I sure don't want to spend my time, money and health that way. There are no benefits short term and long term, the scientists have no idea what the ramifications will be. So quit stating that we are political. No, we just did our reading! Like the Doctors should have, yet they didn't!

Hi Diana,

Are your nose bleeds anterior or posterior? I too had been having them (anteroir) since Nov. It was an enlarged blood vessel that had to be cauterized (tried everything under the sun from a natural perspective) twice. The second doc explained in my case it probably was from dryness. He recommended a humidifier and ayr moistening gel. I notice when applying it, the tissue is dry on that one side. I also use a saltwater nasal spray. Hope your condition has improved.

Thanks for the clarification Art. That's what we used. I'm just awful at my abbreviations.

We also used 50 mg of zinc not mcg. 🤦‍♀️

Praise the Lord, Mama to Many!

That was in awesome family venture. I am so happy for you and your family.

To me one the biggest battles I see families facing since 2020 is a purposeful effect to help one another stay well.

I came to NC to help an elderly Aunt. It has been trying venture to me to get me well and keep her well. I know the Lord has help us.

I happy to say she got the first part of her COVID Vaccine shot. She wanted it so bad, she has Faith in it. So I am happy for her. She's a tuff cookie and still fussing.

Thank God for family and Caring neighbors, and for our EC family.

HisJewel

Love your testimony of good results and tips for others who get caught in the covid storm. I wanted to add that when I was young I had no appetite and felt sick a lot. I started taking B vitamins and noticed that I felt like eating a horse and that was interestin. I finally gained weight and had to figure it out and cut back on how many B vitamins I was eating. 2021 is war and victory and war is always a great reset of all that we thought mattered. Sort of a housecleaning.

Blessings, Charity

Just a post in support of Art's last post on Melatonin. I also think it's worth mentioning that the Chinese researchers quickly confirmed the efficacy and safety of Melatonin for COVID-19 as far back as March this year and, unlike the Western researchers and the FDA, they wasted no time implementing its rapid use in their hospitals. Here is the Chinese research:

https://pubmed.ncbi.nlm.nih.gov/32217117/

China has also donated and shipped large amounts of drugs/herbs to the Philippines (where I live). They shipped Lianhua Qingwen (a COVID-19 anti-viral) and Melatonin as well as other drug/herbal combinations to be used in Filipino hospitals. The Philippine researchers have also wasted no time confirming the efficacy and safety of Melatonin which can easily be purchased from any Asian retailer website like Alibaba and Lazada.

Unfortunately, as Art and I have discovered, Chinese anti-viral herbs like Lianhua Qingwen capsules are not being sold on Amazon (banned by Jeff Bezos?) but they are sold on eBay. So now Amazon has been politicized in support of all that China-hate from all western govts, which is a great shame.

It also appears to me that the perpetration of all that China-hate propaganda in the western media seems to be way more important (sic) than western researchers actually knuckling down and making the effort to find a successful and consistent therapeutic anti-viral cure (with a 95% cure rate) for COVID-19 in order to save lives in the West. That's the way to go, not vaccines. And China is already there with her integrated medicine approach (but this has not being accurately reported or recognized in the West because of all the continual China-hate propaganda emanating from western, govt-led media who are so successfully blurring, distorting or just not reporting all the facts).

Hi Mary Lou.

Thank you for coming back to update on your progress!

Yes, melatonin can cause diarrhea and while it is not a common side effect, it can happen. Here is a quote from my very last reply to you :

>>>I suggest you stop taking vitamin c, magnesium and melatonin as each one of these can cause diarrhea.<<<

..............................

In your case, the diarrhea did not come on for well over a week, which generally would suggest that you tolerate melatonin as in cases of diarrhea related to melatonin use are usually seen right away, at or near the first dose. This may be a good thing for you in case you get Covid-19 again. The antibodies appear to last for months, but apparently it varies with each patient. If you were, to get Covid-19 again, you could still try melatonin at the very beginning and stick with the melatonin until you develop diarrhea again and then stop taking melatonin. Your previous experience will be a very good guide for you!

You may have missed a post I wrote about a specific nasal spray called Xlear, but if you contract Covid-19 again somewhere down the road, I think the combination of melatonin and Xlear, may get you over it quickly and before diarrhea becomes an issue. Here is a link to that post about Xlear :

https://www.earthclinic.com/xlear-for-covid-recovery.html

Now regarding your question about a possible alternative sleep aid to melatonin, I have used Valerian Root Extract (VRE) and it is helpful for sleep. The zinc and magnesium should work well with it. A word of caution regarding VRE, It smells bad, and may be off putting for some people, so again it comes down to trial and error.

Your second question is more involved and would require much more information about what issues you are having that require supplementing.

Thank you again for the update, Mary Lou!

Art

https://www.youtube.com/watch?v=prujdWuCxa8

Fauci: Masks don't work

Mary Lou,

Glad to hear your sleep has improved and even gladder to hear you have fared very well with your bout of Covid!

I think what Dr. Neel is doing is waiting until you test negative and then slowly reduce your melatonin dose until you get down to around 5 mg/night.

I believe the reason he is in no rush to take his patients off of melatonin too quickly is because Covid-19 has shown damage to almost all major organs in autopsies and studies suggest that melatonin can repair much of the damage that you can't see and is not readily apparent to the patient or doctor. This damage if left unchecked may cause health issues years down the road. I think the damage has the best chance of being repaired while it is relatively fresh.

Art

Art, I think you're right about the diarrhea. Anecdotally, person in my office flies to sporting events every weekend. He is one who never covers his coughs. This past week, many of us in the office have had strange stomach pain, joint pain, fatigue and diarrhea. I'm betting we've been exposed to covid and, since we are very aware of supplements/rest/nutrition, we're fighting it off. Maybe a minor infection at this point. But how would we know without testing? And none of us want to be tested because that would shut down our department and we're essential and would have to work anyway unless seriously ill. We do not encounter the public much, so it's purely internal other than at home. And, since we're conscientious about not infecting others, I think we'll be okay. But, sucks for us to have one person bring it in.

Since it appears that Covid-19 is going to be here longer than anticipated by the administration, I am continuing to update this thread as I find relevant information regarding this infection. It is worth noting that overall, since the administration has taken over keeping track of Covid-19, from the CDC, in mid July, the number of new cases for the US have been declining steadily. On July 24th, there were 78,586 new cases that day and it has steadily declined from that day forward. Can this even be correct considering the elevated new cases in California, Texas, Florida and New York?

This recent study (June/2020) is in agreement with the idea of using melatonin against Covid-19, but their hypothesized dose rate is approximately 8 times greater than what Dr. Neel is using on average (1mg per kilogram/day) at 8 mg/kg/day and higher for severe cases! To put that in perspective, if you weigh about 175 lbs or 80 kilos, you would have to take about 640 mg of melatonin per day for severe Covid-19 infection!!!

https://www.melatonin-research.net/index.php/MR/article/view/83/562

I'm a fan of melatonin, but that is the highest dosing I have ever heard of in humans and even greater than what Dr. Shallenberger is using in his stage 4 cancer patients!!

Art

Dear Art,

Thank you for the information!

Yes, as a matter of fact, my mother in law does have A-fib!

She is actually taking a small amount of melatonin right now. She has been in a nursing home for 9 months and when her sleeping pill prescription ended, they asked if they could give her melatonin instead. Well, I was sure happy about that! I don't know how much yet.

I actually didn't realize that COPD is what they used to call emphysema. But it makes sense.

Thank you again!

~Mama to Many~

July update From One of Dr. Neel's Patients Describing Her Experience

This is an update from one of Dr. Neel's patients describing her experience using high dose melatonin (HDM) to treat her Covid-19 case. She adds confirmation to what Dr. Neel has been saying about the rapid onset of action by HDM (High Dose Melatonin).

Also of interest in this update is the fact that Dr. Neel appears willing to go slightly above his proposed dosing schedule of 1 mg of melatonin per kilogram if he deems it necessary.

This is essentially one patient's play by play of her experience with Covid-19 and HDM:

https://devinenews.com/ms-ovalle-shares-battle-with-covid-and-what-got-her-through-it/

Art

Here is the latest update (6/23/2020) from Dr. Neel. It appears that he now has about 100 patients based on what he says in his update and he gives a brief idea of how things are going for his Covid-19 patients and his results are holding up very well as his patient base continues to expand (Texas appears to be having a significant increase in Covid-19 cases) and no deaths to report among his Covid-19 patients!

To me that is awesome news compared to all other major drugs being trialed and tested, as even the best of these are showing patients still dying, but at a lesser rate. Importantly, he once again reiterates the importance of vitamin D based on the Italian vitamin D statistical analysis as it relates to Covid-19 patients. In this latest update you can see that Dr. Neel is becoming even more focused in treating his covid-19 patients quickly and has had no major complications or deaths!

Dr. Neel also mentions the study trial in Manila that will treat 350 Covid-19 patients who also have pneumonia. It seems pretty bold to focus on Covid-19 patients with pneumonia, as this group has a significantly higher death rate!

Here is a link to his latest update:

https://devinenews.com/cases-come-back-with-a-vengeance-melatonin-offers-hope-as-full-scale-clinical-trials-start-on-covid-19/

Art

Hi Diana,

Nosebleeds are not a listed side effect of melatonin, however it does have anticlotting effects and this could cause nosebleeds in sensitive people, especially if you are taking a blood thinner of any type such as Warfarin, Ivermectin or even supplements with blood thinning qualities like vitamin E, Nattokinase, Curcumin, garlic, Bromelain, grape seed extract and fish oil to name only a few. This is part of what makes melatonin and these other supplements useful for heart and vascular issues, but in your case it may be the cause or part of the cause of your nosebleeds.

It sounds like you are not going to be able to use melatonin and now that you are aware of the problem, it will be a good idea to check on the anticlotting and or blood thinning effects of other supplements you may be considering including Ivermectin.

One of the damages caused by Covid-19 is blood clots for which melatonin is quite useful for preventing, but in your case, the nosebleeds would be a problem. This is why I often remind that not everyone can tolerate melatonin.

Art

Greetings Diana Oxfordshire,

This could be a vitamin B deficiency. I would either start taking a b complex 50 or 100 daily, or start taking a teaspoon of Molasses a day.

I sometimes I put a teaspoon of unsulfured blackstrap molasses, and up to a half teaspoon of baking soda in a glass of water and drink it down if I get a nose bleed. I would do this a few days or so to make sure the situation is addressed. Research vitamin B for nosebleed.

HisJewel

Hi PCL,

Thank you regarding my recovery from those symptoms!

If your reason for taking melatonin is to treat Covid-19, you don't need to take it unless you get covid. There was one study where they determined that melatonin may have a preventative effect. Dr. Neel mentioned that there is one anecdotal report where 20 mg may have a preventative effect, but this has not yet been scientifically proven.

If you had the melatonin hangover a couple of years ago at a low dose, you are still likely to have that issue at 10 or 20 mg.

If you do get Covid-19, the daytime sleepiness is likely to be a benefit as many report disrupted sleep with Covid-19. Good luck and keep us posted on your testing!

Art

Thank you for sharing the additional details, Art.

Sincerely,

J.

Hi Sarah,

When melatonin is used as a treatment for Covid-19, daytime drowsiness is probably a good thing, because it allows you to sleep and during REM sleep the body can heal well. The other thing is that you really can't go anywhere if you are infected because your doctor will want you to self quarantine for so many days from the day you first notice symptoms.

When using melatonin for other health issues, two ways that have shown in studies not to cause daytime drowsiness is taking melatonin intravenously or as a suppository. For me, I found that regular use of oral melatonin helped to eventually get rid of the melatonin hangover over a period of about 2 to 3 weeks as the body self adjusts to increased melatonin levels. Staying very active during the day was most useful to minimize the daytime sleepiness.

As I've mentioned many times on EC, not everyone can tolerate melatonin, so if side effects are too much from melatonin, then melatonin is not an option for that individual. The majority of people tolerate melatonin fine, but for those who do not tolerate it, melatonin use is precluded.

Art

Hi Art,

I've enjoyed your articles on melatonin. I have a question with regards to the last discussion you posted and the dosage. You were at quite a high dose compared to what is usually recommended.

Did you titrate up to that amount, and if so, how slowly or quickly did you do that, and does it leave you groggy at all? Thank you for the wonderful service you provide in sharing your information!

Hi Payton,

Liposomal melatonin is fairly expensive and Dr. Neel has not used it in his patients, so he has no data to show if it is more effective than regular melatonin for Covid-19. More importantly, he has no data on how to dose the liposomal form of melatonin.

On Amazon, many of these liposomal melatonin products are $40 for one ounce.

https://www.amazon.com/Biopure-Liposomal-Melatonin-Phospholipid-Natural/dp/B01MPZU9BG/ref=sr_1_6?dchild=1&keywords=liposomal+melatonin&qid=1610306110&sr=8-6

Hi Cheryl,

Tramadol is used for pain, but melatonin can increase the known side effects of Tramadol.

One of the common side effects of Tramadol is a lightheaded feeling like you might pass out! Sound familiar?

https://www.drugs.com/tramadol.html#side-effects

I would advise against that combination to be sure!

There are other drugs that should not be taken with Tramadol and alcohol is a definite NO! Your pharmacist can advise you everything to be careful of with Tramadol.

Art

Hi Annette!

Thank you very much for your feedback on melatonin for Covid-19.

Your results seem to mirror what Dr. Neel has seen in his over 1,000 C-19 patients that he has treated with HDM. He reports rapid turnaround in symptoms very shortly after initiating HDM.

Regarding your husband taking 10 mg and still getting Covid-19, in the symposium that Dr. Neel recently attended, the general consensus among the doctors, researchers and scientists at the symposium, 20 mg was the suggested preventative dose.

Regarding the headache from taking melatonin, this is a known side effect, but in the people who I have talked to with this issue, like the "melatonin hangover", it tends to reduce as the body adjust to more melatonin in the system.

The question I have is, since you started the other supplements prior to HDM, did your husband notice any improvement from them or did he just see improvement once he brought his HDM dose up to par?

Thank you again, Annette for the feedback as it adds further confirmation to the effectiveness of HDM.

Art

Hi Karen,

If you mean 5HTP, it is not the same as melatonin and it does different things than melatonin. If you are in England, I believe that melatonin is by prescription only and it may be a problem trying to get a doctor to prescribe the high dose you would need? Perhaps an EC member from your side of the pond can suggest a source???

Art

Hi Karen,

For people in Europe order at iherb.com. I am from Switzerland and here Melatonin is absolutely forbidden. You get a prescription only after 65 for only 0,5mg. I have ordered the Melatonin, in case somebody near me gets Covid. Fortunately we have not yet have to use it. Good luck M-L

Hi Mary Lou,

Thank you for the great feedback on your Covid-19 / melatonin experience!

Based on what you wrote, it appears that your Covid-19 "preventative protocol" was insufficient to actually stop or reverse the virus progression in your system as suggested by your steady system increase during those first 7 days.

My opinion of your preventative protocol is that most of those components are synergistic with melatonin and can improve the outcome of the melatonin treatment, but without melatonin they are insufficient and I feel that your experience adds confirmation to this theory.

From what I have seen so far with most things being tested for Covid-19, the sooner they are initiated, the better the outcome. Unfortunately you weren't able to actually take melatonin until a week had passed and this allowed the virus to multiply unabated that first week and the increased viral load seems to be confirmed by that continuing increase and worsening of your symptoms in that first week.

Studies of Covid-19 show that increased viral load equates to worsened symptoms and sometimes death, while lower viral loads equate to moderate to being asymptomatic and living.

On the 7th day, your first day of taking melatonin, you already had very significant symptoms and you only took a 40 mg dose of melatonin and that allowed you to get good sleep which is actually very good! Some people say that melatonin can make them feel tired the day after they take it, but it is a good thing to sleep and reach REM sleep where your body is able to do a lot of needed repair work.

Consequently, even though you only took 40 mg of melatonin the night before, you already felt a smidgen better the next morning which was a first! This is exactly what Dr. Neel has been reporting in his patients with noticeable improvement the day after the first dose. Dr. Neel recommends to other doctors to give their patients 1 mg of melatonin for every kilogram of body weight.

I don't know what you weigh, but 80 mg is probably close enough to that dosing schedule to work as Dr. Neel has been reporting in over 400 Covid-19 patients treated successfully so far.

On the 8th day, you actually took your first full 80 mg dose of melatonin that you planned to take. You noticed increased coughing and again, this can be a good indication because one of the first things that melatonin does is reduce inflammation in the lungs and with reduced inflammation and consequently reduced swelling in the lungs, the body will attempt to start clearing fluid and mucus buildup which would represent as increased coughing that should be more productive than previous coughing.

The symptoms on day 8 are to be expected.

Day 9, your second day at the full 80 mg dose again showed symptom improvement and that was to be expected.

You stated, >>> ' I felt fairly good, but shaky, a little dizzy, weak, tired, and coughing a little less. I reduced Vitamin C to every 2 hours.' <<<

Again, you are showing improvement at just your second day of full dosing!

One thing that has been shown by Dr. Neel and studies is that vitamin C has synergy with melatonin, so it may have been a bit premature to reduce the vitamin C dose, but that is unknown for certain in your case. Remember that your original preventative formula mostly has synergy with melatonin.

Day 10 you reported reducing your vitamin C dose even further after getting a little diarrhea. This is where the way the post I wrote on this subject gets a little harder to follow.

You see, whenever I got new information regarding using melatonin for Covid-19, I can not add that information to the original post, so I have to add it as a "reply" to the original post so if you don't read the whole original post "and" all of the replies to that post, you will not get all of the information needed.

In one of my replies I said that in later cases of Covid-19, Dr. Neel is seeing gastrointestinal issues that he did not see in his first 200 patients or so and he surmised that these gastro issues were likely related to a mutation of the viral strain. His solution to the problem was to add an antibiotic to try and kill whatever bacteria was causing the gastro issues, but you were probably not even aware of that update. Now if you were going to try to use some type of natural antibiotic to treat the diarrhea, it would probably be things along the line of garlic, Olive Leaf Extract, Grapefruit Seed Extract, Colloidal Silver etc.

Really just a personal choice based on what you prefer.Day 11 went fairly well with tiredness, a light cough to clear the lungs and more sleepiness which would all be expected on your third day at full dose melatonin. No mention of diarrhea.Day 12 sounds really good and again no mention of diarrhea.Day 13 sounds similar to day 12 and no mention of diarrhea.

Day 14 you said, >>> ' I considered myself healed at this point. ' <<<

On this point I would completely disagree. Your symptoms may have abated, but this in no way means that you are no longer sick! I think that many people think that if they have no symptoms, then they are no longer sick.

You are only on your 7th day of melatonin at full dose and you started a week later than you should have which essentially gave the virus a head start. Chances are you would have still tested positive at that point and to let up at that critical point is a mistake imo.

For myself in a similar situation, I would have continued with everything for at least a week more and I would probably gone even longer than that with the melatonin. Here is why. In the beginning of the original post I am talking about all of the damage that Covid-19 has shown in autopsies to many of the major organs and melatonin has shown the potential in other studies to help prevent or lessen this damage which can in time become long term or possibly life long damage.

It is my opinion, based on melatonin studies, that much of this damage can be prevented or reduced with longer use of melatonin after all symptoms have cleared. No mention of diarrhea.

From day 14, you skip to day 25 and I assume that you are relatively okay during these 11 days.By day 25 you have cut back on everything and are now trying different things to control the diarrhea.

I believe that the ACV with baking soda is a bad idea as you do not want to raise stomach pH as one of the purposes of stomach acid is to kill bacteria that enters the stomach with your food and imo can possibly be a reason for the diarrhea.

Eleven days with no symptoms suggests that you had the virus under control, but reducing stomach acid via your alkalizing method does not seem like a good idea imo.Unless I missed something, none of the things you have been taking seem to have strong antibacterial effects, except curcumin, but it is not well absorbed and would likely require a high dose, but I have no knowledge of using curcumin in this way.

The supplements I mentioned above, do have antibiotic effects as do others. Generally, but not always, diarrhea is caused by a bacteria and in your case you do not know the exact cause at this point, but if you went to a doctor, he might put you on an antibacterial regimen to try and kill any bacteria that might be causing the diarrhea.

ACV by itself might be helpful because of its low pH, but likely insufficient for full blown diarrhea and by adding baking soda to the ACV, you are significantly raising the pH of the ACV and possibly your stomach acid depending on what dose you have been using thus nullifying the possible benefit of the ACV.

Ideally, a visit to the doctor to take and test a stool sample to find out if it is a bacteria and which bacteria and knowing which bacteria would be very useful. With that knowledge he would know the best antibiotic to use. Failing that, you have a decision to make to either go to the doctor or decide if you are going to try and use naturals supplements with antibiotic effects on the diarrhea.

I am not a doctor and can not tell you what to do regarding the diarrhea.This diarrhea situation is questionable at this point whether it is related to Covid-19 or not because you went well over a week with no symptoms or diarrhea and Dr. Neel's reports only discussed earlier onset diarrhea which you did recover from, but those reports are not overwhelming with information.

It is entirely possible that this current diarrhea is unrelated to Covid-19 as even you thought that it might be food poisoning.

Art

I had Covid in March and coughed almost five months without cure. I discovered that quitting all dairy immediately caused my coughing to stop! But still left with difficulty breathing, runny nose.
I found that NAC 600 mg twice a day has really helped.

Then I do a steam as I do not own a nebulizer with Theranaturals glutathione, one capsule and one drop of eucalyptus essential oil. This glutathione is made for nebulizers. Eucalyptus is beneficial for lungs.

I do not do HP.

You could try above.

Covid takes a long time to recover.

Here is a link to a new abstract that suggests that melatonin is useful for restoring the glutathione redox system as well as working against Covid-19!

https://pubmed.ncbi.nlm.nih.gov/32597503/

Art

You might contact a church in your area, tell them your predicament, and ask if they can help. They may be able to send someone to help with childcare.

Q90FM may be able to help, too:

https://www.q90fm.com/prayer.php

🌞

Hi Deborah, Yes, it appears that those supplements and combinations can be very helpful judging by the comments on them across the internet. Vitamin C seems to be most effective through IV, which can be hard to get and is pricey. Liposomal C can be similarly effective as IV vitamin C, but it too is pricey. Zinc can be helpful also, but zinc needs an assisting ionophore such as Hydroxychloroquine or quercetin at high dose in order to help get enough zinc into the infected cells and disrupt the viral replication process. Covid-19 has those spike proteins and these attach or dock to a specific cell receptor and once they dock, they inject RNA into the cell and hijack the cell to turn the cell into a virus making factory until the cell dies and all of the viral particles inside are released and move on to other cells to infect in the same way as the first viral particle did. When enough zinc can enter the cell with the aid of an ionophore, then the zinc can disrupt the viral replication process effectively. Zinc on its own seems to have limited access to the cells. The ionophore assists with cell entry by zinc. Iodine has already been discussed extensively on EC. There are a some specific things about melatonin that make it practical for this purpose. 1. It is relatively inexpensive and although a limited number of cases, Dr. Neel has seen improvement in just one day in his patients so it is fast acting and it alleviates the symptoms making it easier to tolerate the disease while it is active in your system. 2. It has shown that it is effective along side Hydroxychloroquine, and based on the available studies, it has shown synergy with other supplements such as the quercetin + melatonin study in the original post for this thread. 3. Melatonin has a very good safety profile as it should considering the the pineal gland produces it and excretes it every night. 4. Melatonin level peaks around the age of 5 years and the level declines very sharply from puberty on and is very low by the late fifties and beyond, the same age as those who are at highest risk for succumbing to Covid-19, as the chart inside the initial post clearly illustrates. 5. Melatonin is easy to obtain in the US. I don't know if you have shopped for the items on your list lately, but they are simply hard to come by right now, while melatonin is still available the last time I checked. 6. Melatonin actually attenuates part of the immune response so as to greatly reduce the chances for a cytokine storm and allows the immune system enough time to create antibodies to fight the virus the way it should and all the while making more antibodies to destroy the virus. Dr Neel is essentially just using melatonin with oral vitamin C, but the hospital in the Philippines is using melatonin by itself and melatonin + Tocilizumab / Actemra which is a specific IL-6 inhibitor that is sometimes used for arthritis and cytokine storms. The doctor who commented on it said that Actrema and melatonin seem to do the same things. 7. Melatonin appears to be effective on its own which makes it an inexpensive and very simple treatment with a good safety profile while significantly ameliorating C-19 symptoms while further allowing the immune system to do the job it was meant to do! 8. Melatonin in hundreds of studies has shown its ability to protect the major organs of the body and with the latest available information from patient autopsies, C-19 is showing that it is also attacking the kidneys, liver, heart, lungs and possibly the brain because viral particles have been found in the brain. 9. In reality, most of the possible drugs are still being trialed which means they are not available to the masses until one of the trials proves that that particular drug is effective enough and then the FDA will have to review the trial and approve the drug for off label use and all that means that it will be a bit of time until one of those drugs is ready for use by the public for Covid-19. Given the worldwide demand for such a drug, there may simply not be enough available to meet demand, even with a ramped up production plan. Bottom line, will there be enough to go around? This sounds like a pretty good case for melatonin, at least to me it does. Given all of the above, it certainly seems worthwhile to have a conversation with your doctor about melatonin before you actually need to take it. Art

BellaPaolina,

Regarding your first question, that is not an issue I have seen reported in the literature, but melatonin does have blood thinning and anticlotting properties, so in order to find out if it is the cause for the hematoma, try stopping it for a month and see if that resolves the issue. If it does help, and since you are in good health, perhaps you can use a lower dose. Melatonin at 50 mg/day has shown the ability to return elevated oxidative stress levels, in people with disease, back to healthy control levels and this would be very useful for maintaining health long term. Lastly, you can get melatonin naturally by exposing yourself to earlier morning and later afternoon sunlight and get a little vitamin d at the same time. I always recommend this to people who do not tolerate oral melatonin because naturally derived melatonin seems to come with no side effects. I wrote a little about that here :

https://www.earthclinic.com/supplements/how-to-increase-melatonin-naturally.html

Regarding blue light glasses and whether they are useful for preventing eye fatigue and blue light exposure, so far they have not shown a good ability to do that and the following article discusses that topic :

https://www.publish.csiro.au/hc/Fulltext/HC23101

Continued good health to both you and your husband!

Art

I have been taking 20mg of Melatonin for several months and for several reasons. I had Covid very badly in March 2020 followed by many months of long-haul symptoms. I don't want to get it again. I don't sleep well and now I am having investigations for possible Ulcerative Colitis. Melatonin is supposed to help with all of these.

One concerning thing is the past two months I have had nosebleeds every morning. I was reading this thread and was surprised to learn that Melatonin can cause this. Is this true? I've been wondering why I suddenly have chronic nosebleed having rarely suffered in my whole life up to now. I think I will continue with the Melatonin especially if it will help with my gut inflammation (although it has not done so yet but I am hopeful).

Any suggestions, Art?

Art, what do you mean by "some people cannot tolerate Melatonin"?

I have 5mg tabs and they do not put me to sleep and I feel a little hungover the next day. Do I need a higher dose?

If I remember right, I had a sort of hangover from Melatonin I had bought a couple of years ago, for sleep (lack thereof). I am going to at least try it again and see if I feel normal in the a.m. as I feel super good now. At 68, nutrition and exercise are working wonders for my T2 Diabetes, and I am vaccinated with the 2-shot Moderna (Wed will be 2 weeks). I don't want Covid though, and if the Melatonin can help fight it off, it's worth me trying one again. I think you said you take quite a large dose which I see your links somewhere for 10 mg so I'll try that. Another lady said she uses 20mg, but I always start thing low-dose :) Thank you Art, and so happy on your quick recovery of those symptoms!!

I just got a positive test result back for Covid-19 and had the exact same symptoms as you did. Woke up last Wednesday at 5am with chills (some mild body aches and restlessness the previous 2 nights), intense body aches mostly in the legs and hips, intense headache. The chills got worse and caused me to shake and shiver - even put my head under the comforter to try to get warm to no avail. Chest and head congestion but no fever. Heavy chest, and a tickling or irritation on taking deep breaths which then causes me to cough. I've been coughing up green phlegm for several days now, shortly after arising, but it's gettin lighter in color each day. I had been taking melatonin all along but ran out. Back on it now, in higher dosage.

Anyway, I think you got a false negative. If you can get the antibody test that would be interesting to see what it says.

Thanks for your post,

KK

J,

I forgot one other in the melatonin series, COPD and the next one is a very common one also.

Art

Hi BellaPaolina,

Thank you for this information! It is important because melatonin has shown itself to have fairly poor availability estimated to be in the 3% to 15% range, so ways of improving that bioavailability would be useful.

Art

Hello Mizl of Jacksonville FL,

Greetings from HisJewel,

My performance is Regular "Nature Made" Melatonin.

However if you need to stay away from sodium these may not be right for you.

I did not want extra sleep agents, sugar, nor fast dissolve tablets. So ended up with these and I was able to stay active with them all day until I went to bed.

The sleep was only 2 hours then on and off until morning.

However, remember they have sodium.

HisJewel

Hi Art,

My 88 year old mother has covid. No respiratory issues but overwhelming fatigue, extreme muscle soreness especially in the legs and hips and generally feels absolutely awful. I have 10 mg store brand melatonin on hand but am about to head out to purchase some more. Do you take the different forms of melatonin together or separately throughout the day. I'm nervous about the high dose but will take a leap of faith on this with few other options . She's about 130 lbs and will give her 80 mgs per day. Can you confirm that that seems appropriate just for my peace of mind. Don't expect my doctor would know the first thing about this. Thank you!

Hi Nan,

Dr. Neel is using a minimum of 1 mg per kilogram of body weight in most of his patients. They are using significantly more in Manila. Given your mom's weight, if she is going to follow Dr. Neel's protocol, 134 lbs. = 60.7814 kilograms as shown here :

https://www.google.com/search?q=convert+134+lbs+to+kg&rlz=1C1CHFX_enUS601US601&oq=convert+134+lbs+to&aqs=chrome.0.0i512j69i57j0i512j0i22i30l6.14638j1j7&sourceid=chrome&ie=UTF-8

Based on Dr. Neel's regimen, your mom should be taking 60 mg of melatonin in divided doses throughout the day.

Melatonin can interact with other medications so you should either ask her doctor if melatonin is compatible with all medications your mom is taking. If her doctor doesn't know the answer, your mom's pharmacist should. As a last resort, you can call Dr. Neel at (830) 538 - 3550

Here is a link to a video that discusses Dr. Neel's protocol as well as dosing used by doctors in Manila and includes a discussion by Dr. Reiter, a world renowned researcher in melatonin. Very good information for anyone considering the use of melatonin for Covid-19 and other health issues :

https://youtu.be/p_4JeOj1JLc

Melatonin, like all other treatments for Covid-19, works best if initiated at the very first symptoms of infection.

Art

Hello Jacksons Mom,

Here are a couple of links to information on the use of high dose melatonin (HDM) for Covid-19 which you may find helpful.

https://www.earthclinic.com/melatonin-protocol-for-coronavirus.html

https://www.earthclinic.com/supplements/melatonin-research-for-covid-19.html

Art

I just wanted to report this recent news update about melatonin as it relates to Covid-19 :

https://medicalxpress.com/news/2020-11-melatonin-covid-treatment.html

Art

Thank you for explaining. I was hoping to take it as a preventative measure and was wondering how to do that. I will start it at the first sign of illness (if/when I become infected) along with coconut oil, which DOES work on cold and seasonal flu viruses. I can only hope that coconut oil will work on the coronavirus too. Thanks, again, for your response.

I do not have COVID 19 but have had bowel problems for a very long time due to so much anti biotic use over the years for COPD. Recently I switched over to Lauricidin ( a concentrated coconut oil pellet) that I slowly worked up from a 6 count pellet in a scoop to a full scoop., 3xs a day at meals. I can't tell you how much better I feel. Don't have to always keep the bathroom in my sights when going out. Bowels are returning to normal. The micro biome is where we all need to start in our desire to be healthy. Hope this sheds some light on your situation. Carol

Mary-Lou, have you tried buying a different brand of melatonin? It's possible you bought a bad batch. I would buy another bottle and brand from the local health food store and see if it's any different. Just my initial thought.

Hi Art,

I'm not surprised at him using melatonin. Like many things about this administration, it's one rule for them and another for the hoi polloi. Maybe now some people will realize that masks work.

Mary Lou,

I did test melatonin in the sublingual form, but did not notice any difference and the report you are referring to occured around the same time that Dr. Neel reported a more difficult strain of Covid-19 in his patients that was requiring more time to see improvement and in some cases he was using even higher dosing. I suspect that report was reflecting the tougher strain that Dr. Neel had mentioned that also came with digestive issues that he previously had not seen in his covid patients. I believe this may have been the reason for the report of a delayed response in that family.

As far as dosing of zinc, vitamin D and vitamin C, unfortunately they did not state the dosing used, in the article.

One of Dr. Neel's patients in an earlier report mentioned 2,000 mg of vitamin C total per day.

The Italian study suggested a serum level of 40 to 60 ng/ml for a good response to vitamin D, but again vitamin D serum level has to be tested regularly in order to reach a specific level such as 40~60 ng/ml and the dose will vary from person to person as some people simply require higher dosing than others to reach a specific serum level. The reference range for vitamin D / 25 (OH) d serum level is 30 ng/ml ~ 100 ng/ml and would need to be tested by your doctor to get there.

Art

Mary Lou,

I had similar symptoms after what could have been COVID, but didn't get tested. I read on Curezone that we need 150 mcg of iodine a day, some for digestion. The recommendation was to take 100mcg of 5% Lugol's solution a day (16 drops) if you have problems with gut or thyroid AND for COVID. I did and my loose stool was instantly stopped and so was whatever I had (upper and lower respiratory symptoms). It wasn't even minutes. I will continue to take that amount until I get myself iodine saturated.

I also take co factors: Vit c, Selenium 55-400mcg, zinc 25 mg-higher and copper. (I haven't taken the copper yet). I also take a good probiotic.

Hi Mary Lou.

Last time we spoke, I mentioned that you had a decision to make regarding the diarrhea, either go to the doctor or continue trying to fight it with natural substances. You have now tried the latter and the effort has not been successful. You can not continue with the diarrhea as this is preventing your body from absorbing nutrients from food you are eating, so this now leaves the doctor option so that he/she can determine the cause of the diarrhea.

In case the doctor is not able to see you immediately, you can try Pepto Bismol tablets, not the liquid, to help you last until your doctor appointment. Take as directed on the box. The doctor can take a stool sample and also test you to see if you now test negative for Covid-19. From what you have written, it sounds as though the diarrhea is your only symptom, but this is serious and needs to be stopped as soon as possible. A word of warning, the bismuth in Pepto Bismol tablets will turn your stool a blackish green color, so do not be alarmed about that.

I suggest you stop taking vitamin c, magnesium and melatonin as each one of these can cause diarrhea.

Please come back and update us on how it is going for you.

Art

Why melatonin for Covid-19? Melatonin also protects endothelial cells as well as red blood cells being damaged by excess oxidative stress as seen in Covid-19 which can lead to blood clots, while also being the most potent antioxidant in the body ( more powerful than glutathione) that helps to neutralize the significantly elevated levels of ROS that is seen in patients that damages endothelial cells, a potent antiinflammatory agent, an upregulator of the gene expression of the bodies own potent antioxidants, catalase, superoxide dismutase and glutathione peroxidase. Melatonin also scavenges reactive oxygen species/hydroxyl radicals, reactive nitrogen species and peroxynitrite. Melatonin is also protective of all major organs in the body that the virus has shown itself to damage. Melatonin is an excellent protector of the lungs which is very important in Covid-19 to help protect against the cytokine storm. Melatonin acts as an anticoagulant which is very useful in Covid-19 as it has shown itself to cause blood clots. Melatonin also lowers the inflammatory cytokine IL-6, chemokine IL-8, IL-17, inflammatory mediator TNF-alpha, NF Kappa b and IL-1b which are all elevated in Covid-19. There is much more that melatonin does to fight Covid-19, such that if one was trying to create a good drug to fight the effects of the virus, melatonin could possibly be it. Art

Apparently the combination of melatonin and vitamin D may have synergy against Covid-19 health issues according to the following new study. Is anybody surprised? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227533/ I am glad that they released this study, because it is already known that high dose vitamin D lowers native melatonin levels in humans, so having more of both will nullify this issue and likely speed the healing process. I wonder what they will find if they add vitamin C? You just know that this combination is likely to be more effective than any of the drugs which they are continuing to test despite dismal results in Covid-19. EC has the answers and governments and their scientists continue to look in all the wrong places! Art

Cautionary about melatonin… maybe. Just a funny story about my parent's recent experience after I sent my mom this link and some melatonin, just in case they got sick. My dad was gardening with my brother-in-law for a couple of days, and he seemed really out of it. They had a pow-wow to talk about what was going on with my dad. He was super dingy and lethargic, started to be grumpy and kinda goofy, hoarse sleepy voice. It was a marked change; he is a very active grandfather and sharp-minded. He nodded out while having a fourth cup of coffee. Mike says, "Steve, what's wrong with you, are you smoking a lot of pot or taking pain meds?"… Dad says, "no, just the herbs and my anti-rejection meds, Melody (my mom) was giving me!" Mikes ask what it was. "Melatonin." My mom says. "20mg 4 x a day." He's like, "What! 5mg, and I pass out." It turns out my mom skimmed reading the article and didn't realize it wasn't a preventative; it was only to be taken if he was to get sick. We now have a new story about how Grandma was dosing Grandpa. They are adorable and well. I hope we all make it through this new life. Good luck, and thanks for all the info!

Very helpful! However I just got through 6 weeks of Covid 19. No homeopathic remedies came close except for ACV. I drank 3 bottles. I drink it straight.

Thank you for your kind answer. My husband and I are very healthy seniors but since 2021 take 100 mg of MT/evening as an antioxidant and anticlotting agent (in lieu of the baby aspirin) Some more questions:

1- The only side effect I've noticed till now is that whenever I bump into something I get a big hematoma afterwards. Have you noticed this on yourself too?

2- So I assume blue light glasses are not necessary while we use our laptops in the evening?

thank you again for your very informative reasearch, God bless you!

Paola

Hi Art,

Do you think one could do the melatonin along with perhaps ivermectin?

Art, do you take high dose tablets of melatonin? The highest I have seen are 10 or 20 mg. Do you take time release or regular? Thanks

Hi again Art, regarding the bioavailability of melatonin powder as compared to melatonin capsules I have found an interesting article:

Soft gel capsules improve melatonin's bioavailability in humans Sara Proietti, Gianfranco Carlomagno†, Simona Dinicola & Mariano Bizzarri † Lo.Li Pharma s.r.l, R&D Department, Rome, Italy

Objective: Oral bioavailability is one of the most important properties in drug design and development. A poor oral bioavailability can result in low efficacy and unpredictable response to a drug. Several dosages of melatonin have been used for various investigations to clarify its bioavailability in humans. Aiming to search for a pharmaceutical form, which is better absorbed, the pharmacokinetic (PK) profile of the new manufactured melatonin soft gelatin (soft gel) capsule form has been evaluated and compared with the commercially available melatonin powder. Research design and methods: A total of 60 healthy volunteers received 1,3 mg of melatonin powder and 1 mg of melatonin in soft gel capsules. PK profiles were obtained by analysis of melatonin plasma concentration, and the respective melatonin bioavailability was compared. Results: Melatonin soft gel capsule form showed similar PK parameters compared with the highest doses of melatonin in powder form, but its bioavailability was improved. Conclusions: Soft gel capsules improved the bioavailability of melatonin in humans even when administered dose was reduced. Considering the number of conditions in which melatonin supplementation is recommended, this evidence could support a broader use of melatonin in clinical practice

Hope you read this, greetings from south texas

Sorry, yes, it's mg/kg!

Hi Amy,

Some people simply can not tolerate melatonin and that may be the case with you based on how sensitive you say you are to it.

What you can consider and ask your doctor about is Xlear nasal spray which may be helpful. Here is a link to a post I wrote about it :

https://www.earthclinic.com/xlear-for-covid-recovery.html

This is a fairly non invasive approach that showed benefit in a few Covid-19 patients. There are currently 95 other Covid-19 remedies listed on EC. It may be worth looking at some of those here:

https://www.earthclinic.com/cures/coronavirus.html

Art

Glad I could share with you guys. One more thing I forgot to mention was I let the melatonin lozenges disolve under my tongue for maximum absorption. I read that taking tablets, pills, and capsules are not quite as effective because your digestive system doesn't absorb it as well. So putting a disolvable or sublingual form under your tongue gets the maximum amount in your system.

Hey Art!

I'd hoped to circle back with a nice concise report. I am doing well but it has been a bit of a roller coaster.

I'd been experiencing symptoms for a few weeks, but didn't suspect Covid as they didn't fall into what I was hearing. They continued worsening up to diagnosis.

Early symptoms included migraine-type head pain.

Diarrhea, but not as early as headache. Itching-I haven't seen much about this but it was intense. It started on my scalp and then to feet, hands and trunk. Insomnia.

I began HDM the day after my diagnosis. Within 24 hours, ALL SYMPTOMS had significantly improved! The continuous head pain had lessened. Gastric issues cleared up. I did continue to get what I called 'floater' headaches. The pain wasn't continuous throughout the day but came and went.

Do not ask me why but at some point, I thought I was good and cut way back. Symptoms returned with a vengeance.

I went back to recommended dosage of 1mg/kg of body weight. Things got better again right away. Headaches tended to stick around and seemed to be getting worse. I read that melatonin can sometimes cause headaches so again, I cut myself off. Once again, they got worse. I decided to increase dosage. I did this 25% at a time. 25% of my initial dose. It seemed to help until it didn't.

After catching up here, I am going to continue to increase more. I've had issues in the past with headaches but had gotten to a place where I was not having so many. That's about the only symptom that seems to be lingering.

I am over 2 months out, so I suppose I have crossed over to the residual symptom category? I don't know, but I am going to continue to try to get back to pain free. I will not increase up to the 80mg dosage in the report but I will not be afraid to nudge it up some.

Again, thanks so much for your input here and sorry to be so long with update. Stay well!

Karen

Hi Karen,

Thank you very much for the feedback and I am glad to hear that melatonin worked out well for you!

Yes, headache is a known side effect of melatonin and Covid-19. My experience is that the headache generally goes away with continued use, but it is difficult to determine which may be the cause of the headache. Headache is very common in Covid-19, but not much with melatonin. Since you already had the headache before you started melatonin, I would lean toward Covid-19 as the culprit.

The "few weeks" late start with melatonin makes it a tougher battle as Covid-19 has quite a head start to attack all that it is known to attack, but this clearly shows that even when used late, melatonin can still be quite effective against Covid-19, unlike Hydroxychloroquine, Remdesivir and Faviparivir.

Rash and itching have been seen in Covid-19, but itching without rash is less common. The skin is an organ and Covid-19 is showing that it can attack almost any organ in the body including the skin, based on autopsy results.

It seems like the earlier melatonin is started, the better the outcome, but melatonin has also shown benefit for patients who were already on a ventilator when the melatonin was started, improving the outcomes for ventilated patients who received melatonin.

Letting up early after starting late, is likely to be a more difficult recovery, but melatonin is showing that it is up for that challenge.

One person on EC reported that they started at even higher dosing than Dr. Neel's recommended 1 mg per kilogram of body weight at the first symptoms and their symptoms were almost completely gone the next day, so early timing definitely seems to matter!

On a related note, with the variant strains of Covid-19 that are being reported, even if you get a vaccination, it may be worth keeping melatonin on hand just in case the vaccine is not effective against the variant strain that you get. Having a fallback plan just in case seems like a good idea.

Lastly, I still feel that the inexpensive combination of Xlear Nasal Spray with melatonin maybe a good one two punch against Covid-19. Here is a link to a post I wrote about Xlear Nasal Spray and Covid 19.

https://www.earthclinic.com/xlear-for-covid-recovery.html

Thank you again for the feedback, Karen!

Art

Thanks, Art. That's what I told her to do. She already had melatonin, so just took enough to add up to that amount and divvied it up into 4 doses. She started that yesterday as soon as she got home (sent home from work, stopped to get tested) and is, today, up and about like nothing happened. They're harvesting around us, so lots of dust in the air and she thinks she was just reacting to that. Probably.

Art,

10/18/2020, Sunday.

As promised, I'm coming back to relay my experience with Covid and using Melatonin. However, I will make two separate posts. This one will be a continuation of the post for Covid related diarrhea.

This is the 3^rd week of diarrhea. I implemented your suggestions of 50mg Zinc and ¼ cup blackberries a day. I restarted my COVID protocol which included 80mg of Melatonin. I also added Psyllium Husk (5 capsules, 3 times a day). I stopped the High Dose of Zinc and the Psyllium on Saturday. I felt I needed to give the Psyllium a rest and you'd suggested a short term of the High Dose of Zinc.

I did implement your suggestions with Magnesium, Zinc, and Melatonin from your Restful Sleep post.

I was seeing a slight improvement with stools being a little more formed and duration decreasing a little by Thursday/Friday.

Previous to this week there was no diarrhea during the day or evening. This week (depending on what I ate) I would have a very loose movement or two 30 minutes to an hour after eating.

Today the diarrhea is back to mostly liquid and the duration was about 3 hours. Then this afternoon, within a few minutes of drinking water or coffee, I'm back on the commode.

I'm testing Activated Charcoal today and moving to Turmeric. I may have started my doses too close together at the beginning and the Charcoal may have offset the Turmeric.

I work, so taking all these supplements at the right times is challenging. That's one reason I wanted to stop Psyllium.

I will continue to take my Covid Protocol.

Do you have any other suggestions?

3 Month Update:

Again, Jasmine and Art, thank you for inquiring about my status. Carol, thank you for your suggestion.

I found out that the diarrhea was indeed caused by Melatonin. As I posted in October 29th, I stopped all supplements except Melatonin. I was taking 80 mg, and then 40 mg of Melatonin daily from about 9/12/2020 to 10/29/2020.

In Art's post about Ulcerative Colitis and IBD he stated, "The 5 mg dose is a good place to start as some people cannot tolerate melatonin " When I read that In October, I stopped Melatonin too. Within 24 hours there was a dramatic change in my bowel habits – not back to normal but enough of a change to know I'd found the cause of the diarrhea.

However, due to nearly (5) weeks of diarrhea and stomach turmoil, it was nearly another (5) weeks before my bowel movements returned to normal.

I tested 5mg of Melatonin a couple of nights ago, because I had been sleeping so much better when I was taking it. I found out that I'm still Melatonin intolerant as diarrhea returned for a couple of days.

Several folks in my office tested positive for Covid in November so I re-tested even through I didn't have symptoms. I still tested positive. However, I didn't have to quarantine as our Kentucky Health Department told me there is a 90-day rule and I was about day 87. It basically states, that if there are no new symptoms, then the virus is “residual” in your system and not contagious. (I may have my terminology incorrect, but you get the gist of it.)

Bottom line, I've been feeling very good lately. I still have a little cough occasionally in the morning. I clear my throat/lungs and it's gone. I've always had a little sinus issue.

I'm back on most of my supplements and have added

Colloidal Silver, 30 Mg, ½ tsp 3x Day - I'm on my 2^nd bottle and will stop after the 3^rd

1 Tbsp Coconut Oil in coffee at least once a day;

Lysine, ¼ tsp, twice a day;

Black Seed Oil, 1 tsp/day

Hemp Seed Oil, 1 Tbsp/day

My questions now are:

1. Is there something else for sleep in place of Melatonin?

a. I'm still taking Magnesium, Zinc, and D at night and DHEA in the morning.

2. Is there a protocol/suggestion for what supplements are good to take on a daily basis for optimal health? And how much of each. (My pantry is full of supplements and I feel like I'm taking too many and maybe too much of some and not enough of others.)

Thank you for all you and Earth Clinic do to help us.

Hi Mary Lou,

Regarding the blackberries, that seems like a reasonable dose to start with and see how you do with it. Regarding the zinc, I split my dose as the zinc is useful for sleep so I take half of the daily dose about an hour before bed with the other two supplements as I mentioned in my post about pursuit of restful sleep here:

https://www.earthclinic.com/art-solbrig-insomnia-protocol.html

Good luck and I look forward to your update!

Art

Art,

10/18/2020, Sunday.

As requested and promised, this is my post on my COVID experience and using Melatonin. I don't know that it will be sufficient evidence to support any one protocol, but maybe it will help someone.

I've tried to re-create the two weeks that I had COVID as best I can. I was not interested in documenting it at the time, but started after a few days.

My first symptoms were about 6 days after I believe I was infected. On Thursday, 9/3/2020, I had the worse sinus and head cold symptoms I'd had in my life. That was the day I was told I had been in contact with a person who tested positive.

I had been taking a COVID preventative protocol for about a week. These included Alkalizing, Vitamin C, D, Zinc, Querticin.

The next two days I felt better in the morning and worse in the evening.

By Day Four, I felt more flu like symptoms. Very severe head cold and sinus congestion, an occasional cough, and very tired. I went back to earthclinic.com for additional suggestions and the EC staff pointed me to your Melatonin posts. I ordered some.

Day 5 was very bad “flu” like symptoms. I started taking 1000mg of Vitamin C extra times during the day. The highest fever I had as 99.1.

Day 6 still the same. I started taking 1000mg Vitamin C every hour.

Day 7 I received my order of Melatonin and added 40mg that evening to my current protocol. After the first dose of 20mg at 4:00 p.m., I was so sleepy I took a 3 hour nap. After the 2^nd dose at 9 p.m., I slept till about 10 a.m. the next day. I had already started to feel a little better today.

Day 8 I added the full 80mg Melatonin today. It didn't knock me out like the two yesterday. I coughed more today than I had since this started. The worse symptom was weakness, tiredness and being shaky on my feet.

Day 9 I felt fairly good, but shaky, a little dizzy, weak, tired, and coughing a little less. I reduced Vitamin C to every 2 hours.

Day 10 I didn't feel like getting up in the morning. I was more congested. I reduced Vitamin C to every 3 hours as I was having light diarrhea and thought I was saturated with Vitamin C.

Day 11 I felt fairly good except for a little cough in the morning to clear my lungs and still tired and sleeping a lot.

Day 12 I felt fairly good today. I still had a little cough in the morning to clear my lungs. I actually walked about 2 blocks before wearing out. I was still sleeping a lot.

Day 13 I felt fairly good today too. I still had a little cough, congestion, and weakness.

Day 14 I considered myself healed at this point.

Over the next couple of days, I cut back on the melatonin.

Day 25 This was about a week and a half later and later severe diarrhea started. At first I thought it was food poisoning. When that didn't clear, I started back on my COVID treatment protocol including 80 mg of Melatonin.

At first the diarrhea only happened first thing in the morning and lasted 1-3 hours. It started severe, explosive, and liquid. I stayed on the BRAT diet and/or ate light. After (2) weeks, I ate other things and sometimes had diarrhea after lunch or dinner, but only 1-3 movements, then I was usually good.

I started back to work on 10/05/2020 feeling good except for the diarrhea.

I tried most of the popular EC remedies for diarrhea. Charcoal, Turmeric, and ACV didn't help. I added Psyllium and it helped just a little. Last week I upped Zinc to 50mg and ate ¼ cup blackberries.

I felt I needed a break from all the supplements on Friday, 10/16/2020. So Friday night and Saturday I stopped the psyllium and a lot of the supplements. Today, Sunday, 10/18/2020, the diarrhea was back full blown and for about 3 hours.

I wrote a previous post on the diarrhea only and am hoping for more help with that.

Here is my COVID protocol that I implemented over the 14 days I had symptoms:

• Alkalizing with ACV/baking soda
• Iodine 12.5 mg
• Querticin 80mg with Bromelain 165mg
• Zinc 25 mg
• Vitamin C 3000- 10,000
• Melatonin 80 mg
• Multi-vitamin
• B-Complex

I am back on the Full COVID protocol. I had some NAC so I added that too.

I will take Turmeric this week to hopefully help with the diarrhea.

I will say the Melatonin and Art's insomnia protocol has helped me sleep better than I have in years with not as many bathroom trips during the night.

Here is another upcoming melatonin / Covid-19 study that is going to be done in Spain using 60 mg / day and what makes this study different is that they are injecting those 60 mgs of melatonin and this will be a randomized, placebo controlled, double blind study which is also a first when it comes to melatonin / Covid-19. I don't think they have a randomized, placebo controlled, double blind study for Hydroxychloroquine yet :

https://www.docwirenews.com/abstracts/clinical-trial-to-test-the-efficacy-of-melatonin-in-covid-19/

Art

Or the boy's ability to produce melatonin has been compromised.

Hi Art

Would you recommend melatonin for severe Copd and not inhaling H202? Thanks.

Freda,

I answered this question in the original reply I made to Nancy and there is further information re: COPD in my reply to Mama to Many.

Art

Below is a link to a nurse who had Covid-19 and Dr. Neel is her doctor. She gives an idea of what Dr. Neel is like as her doctor :

https://devinenews.com/medina-county-woman-shares-what-her-battle-with-covid-was-like/

Art

GREAT NEWS!!! The latest from Dr. Neel is that over 50 of his Covid-19 patients have recovered using his high dose melatonin protocol!!! https://devinenews.com/50-covid-patients-recover-under-dr-neels-care/ Art

Here is the latest from Dr. Neel who now has at least 20 covid-19 patients and all are doing well on his high dose melatonin/vitamin C protocol. He now has patients calling him from across the country, including New York who he is advising on his protocol! This latest update is very hopeful and continues to show quick improvement in his patients and I would say it is one of his best updates yet! https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/ Art

Thank you Art. I found this quote from the devinenews article you posted very helpful: “As a Ph.D. student I was taught that a virus actively kills our cells during the course of the infection…..But now I know a virus is more like a provoking bully, a bully who continues to provoke cells in our lungs and our respiratory tract to commit suicide……We analyzed the molecular mechanism, how the virus does it, and matched it with scientific databases. Then, came to conclusion that melatonin can block the process that promotes suicide in lung cells,” Shneider said. Source: https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/

Hi Art... Concerning your question about why melatonin has not been already recognized as a successful treatment for COVID-19, it really depends on how much you trust the American drugs companies and the US medical system. For some while now, I've realized that the FDA, in cahoots with the power of the drugs companies, have insured that they are indeed the Lords of Medicine in every sense. To this end, the FDA has already ensured that all research must adhere to their own broken and perverted version of "the scientific method". In effect, this means that the FDA owns ALL the medical laws in America and in the West. These biased laws are, for the most part, mainly used to banish any competing opposition i.e. natural herbal therapies and nutraceuticals. For instance, did you know that melatonin has been ordained by the FDA -- and backed by a Federal Law -- to be a food and not a drug? And according to that law, a substance defined by the FDA as a food can never be used in modern medicine as a drug. Did you know that? That's according to the medical laws already on the statute books in America (and in other Western countries). And that's also why the FDA will never allow food or nutraceutical substances like Melatonin or BHT to see daylight in any US hospital.

Wow, Bill! I was not aware of that point about the FDA! I was aware that the large pharmaceutical companies do what they can to eliminate any competition, even in a pandemic! It is a sad state of affairs for the citizens though, because they are the ones who get hurt in the end. I am glad that there are doctors like Dr. Neel who are willing to buck the system and use something like melatonin rather than push the current list of drugs for C-19 which seem mostly just marginally effective if at all and people still die, so that to me is not my idea of effective! We are fortunate that we have EC to share these ideas that we will likely never hear from our doctors! Thank you for EC, Deirdre and thank you for the information, Bill! Art

Hi Art...I confess that I too am somewhat shocked by the hapless anti-COVID-19 strategies that mostly the western countries are using against COVID-19. These strategies are not working by any stretch of the imagination are they? And when you start sending people back to work when both the infection rate and the death rate are still high then how sensible is that? The governments are saying that they need everyone back at work and the FDA are saying "No, no -- more people will die". Well, they are both right in a way because it's like being stuck between a rock and a hard place. Because if people don't go back to work the national economy will die a horrible death and people will continue to die anyway and if people do go back to work then even more people will likely die. So what should we do? The answer is obvious. All the American and European government leaders should look around at other world nations that have used successful treatment therapies against COVID-19. Oh look, China has got it's death rate down to zero.....How did they do that? Maybe we should talk to them in a friendly way and see if they can help us out? Is America or Europe talking in a friendly way to China to see how they achieved a death rate of zero with a population of 1.3 billion? Not a cat in hell's chance. All the western leaders are all still plying their stupid political agendas, propaganda and misinformation for other lowly political reasons while their people -- their own citizens -- continue to die in high numbers in there own countries. This is particularly true for both the US and UK. And this is exactly what the drugs companies want. They want confusion and fear, because when their fast-tracked COVID-19 vaccines eventually become available in 18 months or so then every western country will be clamoring for a vaccine -- ANY vaccine. That is the really scary part. As far as I can see, there has been no significant research at all on the mutation rate of COVID-19. This is very important because if the mutation rate is too high then the vaccines will not work well. Why do I say this? In 2014, the US CDC actually apologized publicly for the fact for the previous years flu vaccine failed so badly. I mean heck, if our eminent vaccine companies can't even get the simple flu vaccine right then what chance those same vaccine companies getting a much more complex COVID-19 vaccine right? And what about the likely and obvious dangers of rushing through a COVID-19 vaccine in a tenth the time it would normally take to make a regular vaccine? All bad. I've also just read some interesting articles about how Iran who, without the help of any western drugs (because of the US embargo), has managed to quickly flatten her COVID-19 infection rate and rapidly reduce her own COVID-19 death rate. I think China helped Iran initially and now Iran is successfully running with the ball and is currently helping infected people from other countries in her own region because she now appears to have a successful therapeutic treatment for COVID-19. So if our western leaders want you to go back to work and get their economies up to speed again -- without a climbing COVID-19 death rate then, without any doubt, they will need to find a successful therapeutic COVID-19 treatment to achieve that. And what about hydroxychloroquine and remdesevir? I think Melatonin, at 20mg taken 4 times a day with 1000mgs vitamin C, would be far more effective than using both those failed drugs. Melatonin also has a high safety profile. That's my honest opinion from looking at the research.

Even Thailand gets it! https://www.thailandmedical.news/news/breaking-covid-19-supplements-melatonin-helps-lessen-severity-risk-in-covid-19-patients-by-preventing-cytokine-storms Art

Art, Does that mean I shouldn't use melatonin since I am not infected? Because I have gotten one. Thanks.

My question about the blue light glasses was referred to systemic melatonin and the influence of light exposure. High melatonin ingestion coupled with the bright light from laptops at night might damage the retina?

Excuse me for my terrible english, I realize now my question was not formulated clearly. Thank you again from the other side of the ocean!!!

BellaPaolina,

Yes, things definitely get lost in the translation sometimes!

I will have to look for the old study I mentioned, but they were using very bright light in that study which was far brighter than a computer monitor and that light could have been retina damaging on its own. I have been taking higher dose melatonin for over a decade and spend a lot of time on my computer and have not had a problem with my eyes, but I also take my melatonin at night except when I had Covid. In current studies, as I linked to previously, melatonin is retina protective, not degenerative or damaging.

Older studies hold some weight until they are proven incorrect by newer more comprehensive studies. If you have a newer study showing retinal damage, please link to it. I read melatonin studies everyday and have not seen this.

Art

I have not found any newer studies, so I assume that the studies you have linked are correct. Thank you so much for taking the time to answer to my questions. The research you do for Earthclinic is very helpful to many!!!

Paola

Thanks again, Art.

Sincerely,

J.

This is so informative, thank you for sharing. I could've missed this, but how does one avoid drowsiness by taking melatonin throughout the day?

@Jewel, May I ask what brand of melatonin do you use? Thank you in advance.

Replied by DC....here is a great post on nebulizing HP. https://www.bitchute.com/video/tSHJEn04eXlS/?fbclid=IwAR1WcWH8dGachAspYbSVJ5ZH0b0LJvq5rGF8z2YYG0KPuNEm40JpjYL3JKw

Thank you so much for this testimony. It is super useful.

Mama to Many,

Is the melatonin dose you recommend 1mg/kg or 1gm/kg? The latter seems much higher than most recommendations. Thank you.

Hi Art,

I was wondering if one of the side effects of melatonin would be lowered blood pressure. I once took melatonin a couple of hours after taking Tramadol and almost passed out a few times the following early morning. My blood pressure has always been on the low side which is normal for me.

So very grateful for this information, Art. I have just received a positive test so have ordered some HTP which seems to be the same product. It was confusing to buy over here to say the least. I will let you know how it goes. They arrive in two days as today is New Year.

Thank you again!

Karen

Jasmine, Art,

Thank you for inquiring. My last post was 10/29 so I will resume at that post to keep the info in some logical order.

I recently started taking gaba for sleep, but I also include a little melatonin. Have you tried theanine or niacin? For the virus, I would increase the cs. I make my own and drink several ounces a day. :)

Art,

Thank you for a quick reply. And thank you for the suggestion of Valerian. I had taken it some time ago and will start again. I did get a weighted blanket, and after a "getting used to" period, I think it has helped some.

As far as the 2ne question about the supplements, I don't have any current issues to address. I just like to take supplements to maintain good health.

I usually take a multi-vitamin with minerals, extra D, extra C, and extra Zinc. I've added a few other supplements since I've had Covid - Iodine, lysine, Hemp Seed Oil, and MSM.

Are you permitted to recommend a Multi-vitamin brand that is good? There are so many to choose from.

So my 2nd question was, basicially, what Supplements are good to take to continue to maintain good health? Is there a post or a list of basic "good" stuff to take to maintain health?

Hi Mary Lou.

Generally I prefer to take supplements on an as needed basis. It sounds like you are taking some good supplements already, but a B vitamin multi such as B-50 might be a worthwhile addition to your current regimen.

Art

Maybe he made them read EarthClinic yesterday.

Hi Mary Lou,

First I would like to say thank you for coming back and updating on your use of melatonin for Covid-19 as this information is very useful for other members to help know what is useful!

Yes, I think you lessened your dose to soon. As for the diarrhea, Dr. Neel mentioned that in his more recent patients he was seeing gastrointestinal issues regularly and he felt it my be a different strain of Covid-19 than he had previously been seeing. You can try zinc at 50 mg/day for a short course to see if it is enough to regain normal digestion. Dr. Neel added antibiotics in some cases where he suspected bacterial infection.

You can also consider blackberries for the diarrhea.

If you have time, could you give us an idea of your experience with melatonin for Covid-19 and the dosing that you used throughout the treatment period? Thank you!

Art

Thank you again, Art.

I will come back and fill in my usage of Melatonin for Covid, but for this post, would you elaborate on using blackberries? For example, try 1/4 cup once a day...

I will start Zinc tonight. Do you recommend 50 mg at once or divided morning and evening, or ....?

Mary Lou,

Here is a link to Ted from Bangkok's lysine anti-viral remedy. This link deals with H1N1, which is similar to the COVID-19 virus. The post also contains a list of other remedies against such viruses that also includes using Hydrogen Peroxide, MMS, Aspirin etc:

https://ted.earthclinic.com/cures/h1n1-swine-flu7.html

H2o2 use and melatonin:

I have just got over a median case of covid. I have copd and my breathing has worsened since, I just started taking or doing the hp protocol today. I have noticed in your article that melatonin fights off h2o2, so would it be advisable to say I should just do the melatonin to try to recover my lung capacity, I am not on any meds at this time.

This new article explains how melatonin inhibits the cytokine storm that is proving to be a serious problem from Covid-19 : https://www.sciencedirect.com/science/article/pii/S2590098620300312?via%3Dihub Art

Apparently, the Doctors Hospital in Manila, Philippines has gotten funding to do a clinical trial of high dose melatonin (HDM) in 350 patients with "Covid-19 and pneumonia or other Covid-19 related high risk features" based on their experience of successfully treating their Covid-19 patients with HDM. They still have not publicly released their Covid-19 patient data that they said they were going to publish in a scientific journal, but they did manage to get funding for this study based on their initial experience with HDM and the study is being funded by their Department of Science and Technology (DOST). They also mentioned that melatonin is being used in other countries for Covid-19. They further stated that the trial will last at least 4 months which suggest that the results will be available near halloween. https://news.abs-cbn.com/news/06/12/20/dost-allots-p98-million-for-melatonin-clinical-trials-to-treat-covid-19 Art

Hi Jessica.

In the following 2020 article link below, it basically says that there is insufficient data to prove that melatonin is safe when pregnant and although there are tests being conducted for that purpose, that data is not yet available.

Another important point is that with Covid-19, it requires dosing that is magnitudes higher than what would be used for sleep. Bottom line is that there is no data for high dose melatonin in pregnancy, so melatonin is not a viable option for you.

https://womensmentalhealth.org/posts/update-2020-melatonin-pregnancy/

Art

But melatonin is related to the body's sleep modes ...how can that stop a virus? The body has its OWN inbuilt protocols for resisting infection and disease ... you can't ameliorate an infection using stuff that doesn't deal directly with that infection where it matters ... in the cells! In the case of virus, it's Zinc that prevents viral replication and it's Quercetin that puts it there! Now its taken that if you have LOW levels of vitamin D .... then you are a sitting duck ... and the majority of the vulnerable have that due to inability to get out in the sun coupled to a surfeit of toxic drugs courtesy of doctors making profits! HIGH Vitamin D is protective meaning that its renders infection much harder to gain a foothold ... it is NOT however a treatment once you have that virus ... that needs ultra high levels of Vitamin C ... known as LVC coupled to Zinc supplemented ... Zinc Picolinate is the best absorbed!

Hi, Steve, Yes, melatonin does affect sleep, but it does way more than that! Melatonin does not stop the virus, but it reduces the the innate immune response which is what can trigger the potentially deadly cytokine storm and inhibits the potential for pneumonia and thus eliminates the need for a ventilator, three important actions associated with death in Covid-19. Melatonin also is protective of all major organs of the body which in autopsies have all been shown to have been attacked by the virus, including the brain, liver,kidneys, pancreas, spleen, eyes, skin, lungs and heart. Dr. Neel is able to turn his patients around in just 24 hours after starting them on HDM! By not attacking the virus directly, the body can then use its adaptive immune response to create antibodies that will fight the virus as the body is supposed to do. Kill the virus too fast and the body may not be able to generate enough antibodies before the virus is eradicated and this is important in case the virus comes back each year as other Coronaviruses have and scientists are indicating is very possible. By having adequate antibodies in your system, the body should be able to eradicate the virus on its own next time around. In hydroxychloroquine studies that used zinc and azithromycin, the zinc has not shown effectiveness even though hydroxy is supposed to act as an ionophore to help the zinc to have better cell access. Yes, people still died with this combination! Art

Does taking the high dose melatonin cause drowsiness since its a sleep aide. I want to start taking it but am not sick at this time for prevention off Covid???? I have been exposed and want to be proactive and start on regimen before I do become ill.

Someone posted that melatonin does cause next day drowsyness at first, but after you take it for a while it does not.

Meg, I agree and found that an interesting statement that goes against what many people think when it comes to viruses! I think that kind of thinking is helpful to looking at Covid-19 in a different light in order to come up with a better answer like melatonin. The current methods being deployed to fight SARS CoV-2 are proving to be only marginally effective at best, yet these methods continue to be the standard of care as people continue to die from Covid-19. Unfortunately the powers that be continue to ignore melatonin which according to Dr. Neel is easily more effective than any of the drugs currently being tested based on his experience with his Covid-19 patients. Art

It has become well established that Diabetes is a significant risk factor when it comes to Covid-19 so it is good to know that melatonin can reduce many of the factors that are elevated in diabetes such as CRP, A1c, IL-6, Serum Ferritin, chemokine IL-8, ESR, Fibrinogen, oxidative stress, inflammation and Serum Ferritin. https://www.ncbi.nlm.nih.gov/pubmed/32416321 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/ Art

One problem that seems to come with a cytokine storm and pneumonia, assuming you survive both, is significant damage to the lungs in terms of fibrosis and scarring as outlined in the article link below. Although not talked about a tremendous amount, this can become a long term problem well beyond when you are cleared of the virus. In some cases, possibly for the rest of your life if the damage turns into scarring. https://www.sciencenews.org/article/coronavirus-covid-19-some-patients-may-suffer-lasting-lung-damage So far, Dr. Neel and the doctor in Florida have not mentioned this problem in their patients who they have given high dose melatonin (HDM) to! In fact, so far, they have not seen many of the complications that other doctors who are treating Covid-19 patients have reported. What Dr. Neel is seeing in his HDM treated Covid-19 patients is rapid recovery with no apparent complications. This bodes well for the potential to entirely avoid these long term lung complications associated with Covid-19. No cytokine storm, no pneumonia, no lung complications, no ventilator are so far what Dr. Neel has reported in his patients! Just one more reason to consider HDM with your doctor's guidance should the need arise! Art

Since I tend to look at melatonin plus vitamin C as a potential way to open up the economy in a somewhat safer way, I thought that the following videos, although not related to melatonin, might also add to the safety of "reopening". My apologies if it is old news here on EC. https://www.youtube.com/watch?v=wfc6QdBiRK8 https://www.youtube.com/watch?v=rhfh5XBzyFA Given that the current Covid-19 tests are notoriously inaccurate, this seems like it is likely to be more accurate with instantaneous results! Art

Dr. Neel is now at 17 patients as of 5/13/2020 and reports that all are doing well using his melatonin protocol with vitamin C! Another doctor in Florida has reported similar results in her two Covid-19 patients! https://devinenews.com/dr-neel-continues-treating-covid-19-patients-all-across-the-country/ Sadly, the only scheduled trial for melatonin is only going to be using 2 mg / day of melatonin. I don't understand why they even bother at that dose! Art

Art, I really don't understand the high dosages listed above! I bought 10 mg melatonin because that was the highest I could find in my store. My husband and I took it for about a week but it is just too much. Feel groggy and sleepy the next day well past noon. I wouldn't be able to function if it was a higher dose! How is this possible?

Annette, the way I understand it is: if you are ill, higher dosing is appropriate. If not, and you are just taking it for prevention, why would you need high dosing? Personally, I always prefer the lowest dose of anything I try until a need for higher dosing shows up.

This is a common issue that people experience, but for most, the "melatonin hangover" gradually goes away after a couple of weeks. What I have tried that has helped is taking the dose earlier in the evening. So if I feel groggy for about two hours after getting up in the morning, I might try taking my dose a couple of hours earlier. Failing that, you can consider just taking it if you get Covid-19. The extra rest may be helpful at that time and Dr. Neel has had very good success treating his patients who were already infected. I have experimented at multiple dosing levels up to 180 mg per night recently and I find the melatonin hangover goes away much sooner and now I seem to tolerate most dosing well. The highest dose I have heard of in a human study was 1,000 mg for thirty days, but I'm not sure why you would ever need such a high dose. I believe animal studies have gone higher and according to Dr. Reiter, he has never had an animal die at any dose. Art

Dr. Neel is currently at 14 patients and according to him, all are doing very well. This is a far cry from what the reports are saying about the drugs that are currently being tested for Covid-19. With any of those drugs, people still die! It just seems odd that they will not even consider testing melatonin when they already know that none of the current drugs being tested are showing as good results or even just fair results. Melatonin, from hundreds of previous studies has already shown that its multiple methods of action are very likely to have a very significant impact against Covid-19, but the direction seems to remain testing drugs that are not doing much of anything against this virus. In the meantime, people continue to die. Melatonin has a better safety profile than any of the drugs being tested. Melatonin is available over the counter here in the US and production can be ramped up quickly if it proves to work because there are multiple manufacturers already making it. Here is an incomplete list of everything that they currently know Covid-19 can do to humans: 1. Heart attacks 2. Strokes 3. Neuronal damage 4. Liver damage 5. Kidney damage 6. Damage to the spleen 7. Skin damage 8. Heart damage 9. Lung damage 10. Pneumonia 11. Loss of taste and smell 12. Kawasaki or Kawasaki like disease 13. Seizures 14. Death 15. Damage to the eyes 16. Blood clots 17. Damage to the endothelium 18. Oxygen deprivation 19. Fibrosis 20. Damage to the brain 21. Cytokine storm 22. Covid-19 toes 23. Tissue damage throughout the body 24. Organ failure 25. Fever and oxidative stress Just about any of the above items would require significant treatment, but with Covid-19, you are almost guaranteed to get at least 5 of these symptoms, which means that it is like your body is fighting multiple diseases all at one time! Melatonin is known through studies to ameliorate symptoms related to this whole list. Furthermore, it is one of the most potent antioxidants in the human body and it upregulates gene expression of the most potent antioxidants of the body and has potent antiinflammatory qualities which are thought to potentially prevent the potential for a cytokine storm. Having this many things going on in the body at one time will certainly deplete the natural antioxidant defense system which means the elevated levels of ROS is going to be causing cellular damage throughout the body and melatonin will definitely bring that elevated ROS level down. Given the above, it seems like melatonin would be high on the list for potential drug candidates to treat and test against Covid-19, but such is not the case. I wonder why that is? Art

Hi, Bill, Okay, but can you tell me what you really feel!!! I agree 100% with what you said, sadly. Here, it seems to always come down to money and or politics. I was hoping that the pandemic might change things, at least for a moment,but that is obviously not the case, but I certainly don't see a problem with asking other governments who seem to have a handle on Covid-19, what they are doing to make that happen, but that doesn't seem to be happening either. I think of the combination of melatonin and vitamin C (M+C) as a possible way to move forward in a safer manner as the government begins to reopen the economy because opening is assuredly going to cause an increase in new cases and deaths. Yes, more people will get sick at a faster rate with the reopening, but M+C shows the potential to lower that death rate significantly if Dr. Neels success with his C-19 patients is any indicator. Thank you for the comments and information! Art

Trina, I'm glad you posted about your mom and dad's experience. This is why I say to include your doctor in a decision to use melatonin for this purpose and to also make sure it will be compatible with any medications that you may be taking. Dr Neel has not yet mentioned a dose to take before actually being sick, only after symptoms appear and you test positive. Some people are more sensitive than others to melatonin. Another point that your mom may have missed is that the actual dose range that Dr. Neel is using is between 50~100 mg / day depending on the size of the person and the severity of symptoms. Well, it sounds like if your dad ever has to use it, he will be getting plenty of rest! Art

They are getting it, thanks to you, Art! You published on April 20 and finally news publications are picking up on it 20 days later. Thank YOU!!!

Megan, Thank you for saying so. My interest is in sharing the information and hoping people realize that melatonin looks likely to do more than any drug the governments are currently testing for Covid-19! You would think with Dr. Neels results so far that researchers would be all over melatonin, but such is not the case. At least we have the information here on EC to add it to our tool box of Covid-19 tools! Art

I got excited for a moment when I saw this future study that said it was going test melatonin against Covid-19 in patients and then I read a little further and saw the dosing schedule they are going to be using just two milligrams of melatonin vs placebo. I think I can save them time and money and just say don't bother, because 2 mg of melatonin at best might improve your sleep and that's about it! https://clinicaltrials.gov/ct2/show/NCT04353128 Art