Cardiovascular Disease (CVD) and Melatonin

The following article link below was just released today regarding melatonin and Cardiovascular Disease (CVD) which adds further confirmation to the idea that melatonin is very useful as a treatment to help prevent or treat CVD!

This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :

https://www.cureus.com/articles/47653-relationship-between-melatonin-and-cardiovascular-disease

Here is a direct quote from the article that is interesting:

>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<

Art

To update this article on CVD and melatonin, this new study (April 2022) shows that in myocardial infarction(MC) (heart attack), even if you haven't been taking melatonin regularly, if it is given within 3 hours after the MC, it can have positive health effects over the near term and long term compared to not getting melatonin :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000067/

Here are some relevant quotes from the study :

' This pilot study demonstrated that compared to placebo, melatonin administration was associated with better outcomes in AMI patients undergoing primary percutaneous coronary intervention. '

' At 2 years of follow-up, 13 (13.8%) patients suffered the primary endpoint (3 deaths and 10 readmissions due to heart failure), 3 patients in the melatonin group and 10 in the placebo group. '

' The hypothesis-generating analysis found a relation between treatment effect and ischemia time and the authors concluded that melatonin administration within 3 h of ischemia onset reduces myocardial infarct size by approximately 40%. '

' The results of this pilot study indicate that treatment with intravenous melatonin in patients with AMI undergoing primary percutaneous coronary intervention is associated with a reduced incidence of death or readmission due to heart failure. '

This is the first study that I have seen using melatonin in people that have just had a heart attack and the results are quite impressive! The attached graph clearly shows that melatonin significantly improved longer term survival with just one dose given within 3 hours after MC. What this study doesn't show is what would have happened had the patients continued to take melatonin for the full study length of 800 days beyond the single dose given at the hospital.

Art

Hi Baldev,

What was your diet when your arteries were blocked 99%, 95%, and 90%?

If my arteries were almost completely blocked, I would not wait. I would not postpone, or delay.

I would concentrate my attention on that issue. I would take action ASAP, even if I had very little or no symptoms.

Time is, or seems to be, of the essence. I would do something, anything, in order to unblock my arteries ASAP.

You are, or seem to be, playing with your life. No, I would not wait, delay, or postpone. This is not the time to waste time trying to experiment with Melatonin, play golf, and or do something else that is, or seems to be, unrelated.

Yes, you might need surgery. However, surgery is probably not the only option.

For starters, I would ask for an "ultrasonic carotid artery color Doppler ultrasound" - this is a harmless, non-invasive, non-carcinogenic test for the determination of the amount of plaque that can be seen in your carotid arteries.

I hope this helps.

Hi Baldev,

While the studies do confirm that melatonin is very beneficial for the heart and in warding off heart disease in general, there are no studies that suggest it can treat a very serious existing heart condition as you seem to have. You said you were admitted to the ICU for 4 days just 18 days ago! The fact that they kept you in ICU for 4 days seems to make it clear it is a serious condition.

This is well beyond the scope of seeking advice on an internet health forum. You need an experienced cardiologist to advise you on your best options and hopefully one of those options will include melatonin, but I am not a cardiologist and am not qualified to advise you how to deal with your serious heart issues. For that you need a real cardiologist with experience and training in that specialized field.

Regarding being my friend, I would tell any friend the same thing for such a serious condition. I'm sorry that I can't be of any help for you in this matter.

Art

This new animal study (January 2023) shows that melatonin works to reduce aortic wall thickness in the tested animals fed a high fat diet :

https://www.cureus.com/articles/128955-effects-of-melatonin-supplementation-on-the-aortic-wall-in-a-diet-induced-obesity-rat-model#!/

Here is what the study concluded :

' The administration of HFD to Wistar rats led to pathomorphological and morphometric changes in their abdominal aorta, which constitute the main diagnostic criteria of endothelial dysfunction. Melatonin supplementation regressed vascular wall remodeling and restored its functional capacity. '

Aortic wall thickening is a common component of cardiovascular disease (CVD) and reducing that thickening and restoring capacity is a huge step in reversing CVD. So this study adds further corroboration to the value of melatonin in fighting CVD.

Art

While many studies show multiple methods by which melatonin helps prevent or treat cardiovascular disease, this study link below suggests that melatonin also helps reduce vascular calcifications :

https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12631

This is a quote from the study :

' Our results indicate that MT can potentially be used in the therapy of vascular calcification and ageing by targeting exosomal miR-204/miR-211. '

If you are wondering why reducing vascular calcifications (VCs) is important, according to the following article, VCs can increase your risk for heart attack, stroke, dementia, renal insufficiency and inadequate blood supply to arms and legs :

https://share.upmc.com/2018/09/what-is-vascular-calcification/

Art

Hi Art,

I remember in one of your posts you mentioned that you take the maximum dose of Melatonin in the night. I had recently some concern with my heart and have refused to take the doctor's protocol of alopathic medicines.

I have started on Melatonin and am comfortable with that, presently I have reached to 20Mg in the night. I tried taking during the day too but I feel zomby so I am avoiding during the day. My age is 83+yrs wt.52kg and active person exercising practically every day. Three days a week try to play nine holes of golf, and practically have a drink every evening. I want your help to make a sort of protocol of Melatonin that how much I could take in the night and if it is necessary to take during the day how much minimum I should try to take without it affecting me to drive to the club, whether alcohol does adversely effect with Melatonin. All these doubts are there in mind. Presently whatever I am doing it"s giving me a good feeling and I am happy with the situation. If any thing else I should add it will be great.

Your help will be highly appreciated

Thanks and God Bless You

Baldev

Hi Tina,

No, your calculations are incorrect. Your dosage would be around 43 mg.

Here's our dosing calculations page.

https://www.earthclinic.com/cures/covid-19-melatonin-testimonials.html

P.S. I've done 50mg in a night a number of times, no problem.

Melatonin is available in 60 mg dosage and often used for cancer prevention and treatment with its master antioxidant properties.

Baldev,

You said,

>>> ' Presently whatever I am doing it"s giving me a good feeling and I am happy with the situation. ' <<<

To me that sounds wonderful at 83 years of age! If it ain't broke, maybe you shouldn't try to fix it.

Art

Hi Art,

No, I think I have not been able to express myself correctly. Problem is there I have a cardiac history. In 1999 I was advised to go through triple bypass surgery because my three arteries were blocked 99%, 95%and 90% and I had no symptoms but I got my angiogram done just to check because I had retired from active flying duties. I was told that my coletrals were vey well formed and so I was passing my medical exams every six months.

I have come so far, I changed life style followed Ted"s advice. Once in a while I do get in to the problem get admitted in the ICU get stabalised come back follow my regimen ( not any thing in particular) . Once I read your article on Melatonin I started taking it, then I had on 10th April while playing golf some angina type feeling in the chest, on 11th I got admitted in ICU t.hey kept me there for four days and asked me to go through the surgical procedure, which I refused and back home. This is my background and want to pursue Melatonin treatment, if you can help in that I will be grateful.

You do mention about your friends, so I want to be your friend so that I can communicate with you at the personal level and that's why I asked your number/email address.

I have a feeling, with your help I can continue healthy for more number of yrs playing golf.

Regards

Baldev

I take 50 mg fast dissolve melatonin and 20 mg timed release every single night and still can't sleep. Everyone is different.

There are informative books, youtube videos, articles about melatonin. After research by Dr Shallenberger, Prof. Dr. R Reiter and John Lieurance, I started taking high-dose melatonin for a couple of medical conditions. I need a GP prescription and compounding chemist/pharmicist to get the melatonin. Shallenberger mentions two sources in the USA.

I have formulas that have worked in treating Tardive Dyskinesia, things that treat Anxiety, etc., but big PHARMA makes Billions of dollars selling their products to the public, even with major side effects and even death. I will say that if you have heart disease, you most likely have hypertension, just like me, but I take lisinopril for hypertension and tried Melatonin for sleep, the reaction was “MY HEART STARTED POUNDING, AND POUNDING, MY BLOOD PRESSURE ROSE BY 90 POINTS, all because I used Melatonin, so be careful what you read about CVD and Melatonin if you're taking lisinopril. I research things that conventional medical doctors don’t, and won’t unless it’s by big PHARMA.

MD’s aren’t trained in alternative meds nor Nutrition, so when you tell them you want to use ——— for Severe Anxiety, their reply is "Don’t"!

Hello Art,

Terrific article but….1 kg take 1 mg melatonin. I am 90 pounds and I would need to take 298 mg melatonin? That is nuts! I am sorry if My husband or I take over 10 we are groggy and can not wake easily in the am , and my husband weight 175.

This really makes no sense but all else is terrific. I cannot believe you can take 106 mg and over?!

Tina

GertJr,

Where do you find 50mg or 60 mg.? dr prescription?

The best I can find bulk is 15 mg, 400 tablets per bag on amazon.