Cold Sores: Tried ALL of the home remedies, drugs and L Lysine for prevention..... Nothing worked. Read on the genital herpes site that Orange, Grapefruit and Cranberry Juice causes outbreaks. Past years would have on average of 8 major occurrences per year. Stopped drinking these juices and had 1 minor occurrence in the past 2 years (side-note, the last two years have been anything but stressless so its not due to a low stress levels).